Enantiomers of 2-methylglutamate and 2-methylglutamine selectively impact mouse brain metabolism and behavior

Imbalance of excitatory and inhibitory neurotransmission is implicated in a wide range of psychiatric and neurologic disorders. Here we tested the hypothesis that insertion of a methyl group on the stereogenic alpha carbon of l-Glu or l-Gln would impact the γ-aminobutyric acid (GABA) shunt and the g...

Descripción completa

Detalles Bibliográficos
Autores principales: Wawro, Adam M., Gajera, Chandresh R., Baker, Steven A., Leśniak, Robert K., Fischer, Curt R., Saw, Nay L., Shamloo, Mehrdad, Montine, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047011/
https://www.ncbi.nlm.nih.gov/pubmed/33854131
http://dx.doi.org/10.1038/s41598-021-87569-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047011/
https://www.ncbi.nlm.nih.gov/pubmed/33854131
http://dx.doi.org/10.1038/s41598-021-87569-1

Ejemplares similares