Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer

High-grade serous cancer (HGSC) accounts for ~67% of all ovarian cancer deaths. Although initially sensitive to platinum chemotherapy, resistance is inevitable and there is an unmet clinical need for novel therapies that can circumvent this event. We performed a drug screen with 1177 FDA-approved dr...

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Detalles Bibliográficos
Autores principales: Silva, Vera L., Saxena, Jayeta, Nicolini, Francesco, Hoare, Joseph I., Metcalf, Stephen, Martin, Sarah A., Lockley, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047034/
https://www.ncbi.nlm.nih.gov/pubmed/33854036
http://dx.doi.org/10.1038/s41419-021-03665-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047034/
https://www.ncbi.nlm.nih.gov/pubmed/33854036
http://dx.doi.org/10.1038/s41419-021-03665-0

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