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Bilirubin Induces Pain Desensitization in Cholestasis by Activating 5-Hydroxytryptamine 3A Receptor in Spinal Cord

BACKGROUND: Cholestasis patients often suffer from pain desensitization, resulting in serious complications in perioperative period. This study was aim to investigate the mechanism of bilirubin in cholestasis mediating pain desensitization through 5-hydroxytryptamine 3A (5-HT(3A)) receptor activatio...

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Detalles Bibliográficos
Autores principales: Kong, Erliang, Wang, Hongqian, Wang, Xiaoqiang, Zhang, Yan, Zhang, Jinmin, Yu, Weifeng, Feng, Xudong, Sun, Yuming, Wu, Feixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047141/
https://www.ncbi.nlm.nih.gov/pubmed/33869168
http://dx.doi.org/10.3389/fcell.2021.605855