Autologous antigen-presenting cells efficiently expand piggyBac transposon CAR-T cells with predominant memory phenotype

The quality of chimeric antigen receptor (CAR)-T cell products, including the expression of memory and exhaustion markers, has been shown to influence their long-term functionality. The manufacturing process of CAR-T cells should be optimized to prevent early T cell exhaustion during expansion. Acti...

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Detalles Bibliográficos
Autores principales: Nakamura, Kayoko, Yagyu, Shigeki, Hirota, Shogo, Tomida, Akimasa, Kondo, Makoto, Shigeura, Tomokuni, Hasegawa, Aiko, Tanaka, Miyuki, Nakazawa, Yozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047430/
https://www.ncbi.nlm.nih.gov/pubmed/33898630
http://dx.doi.org/10.1016/j.omtm.2021.03.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047430/
https://www.ncbi.nlm.nih.gov/pubmed/33898630
http://dx.doi.org/10.1016/j.omtm.2021.03.011

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