Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Benzopyran-Based Inhibitors

Inhibition of the insulin-regulated aminopeptidase (IRAP) improves memory and cognition in animal models. The enzyme has recently been crystallized and several series of inhibitors reported. We herein focused on one series of benzopyran-based inhibitors of IRAP known as the HFI series, with unresolv...

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Detalles Bibliográficos
Autores principales: Vanga, Sudarsana Reddy, Åqvist, Johan, Hallberg, Anders, Gutiérrez-de-Terán, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047434/
https://www.ncbi.nlm.nih.gov/pubmed/33869280
http://dx.doi.org/10.3389/fmolb.2021.625274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047434/
https://www.ncbi.nlm.nih.gov/pubmed/33869280
http://dx.doi.org/10.3389/fmolb.2021.625274

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