A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology

BACKGROUND: Nucleic acids are potent stimulators of type I interferon (IFN-I) and antiviral defense, but may also promote pathological inflammation. A range of diseases are characterized by elevated IFN-I, including systemic lupus erythematosus (lupus). The DNA-activated cGAS-STING pathway is a majo...

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Detalles Bibliográficos
Autores principales: Prabakaran, Thaneas, Troldborg, Anne, Kumpunya, Sarinya, Alee, Isara, Marinković, Emilija, Windross, Samuel J., Nandakumar, Ramya, Narita, Ryo, Zhang, Bao-cun, Carstensen, Mikkel, Vejvisithsakul, Pichpisith, Marqvorsen, Mikkel H.S., Iversen, Marie B., Holm, Christian K., Østergaard, Lars J., Pedersen, Finn Skou, Pisitkun, Trairak, Behrendt, Rayk, Pisitkun, Prapaporn, Paludan, Søren R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047499/
https://www.ncbi.nlm.nih.gov/pubmed/33813142
http://dx.doi.org/10.1016/j.ebiom.2021.103314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047499/
https://www.ncbi.nlm.nih.gov/pubmed/33813142
http://dx.doi.org/10.1016/j.ebiom.2021.103314

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