Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput in silico screening

Small molecules that bind with high affinity and specificity to fibrils of the α-synuclein (αS) protein have the potential to serve as positron emission tomography (PET) imaging probes to aid in the diagnosis of Parkinson's disease and related synucleinopathies. To identify such molecules, we e...

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Detalles Bibliográficos
Autores principales: Ferrie, John J., Lengyel-Zhand, Zsofia, Janssen, Bieneke, Lougee, Marshall G., Giannakoulias, Sam, Hsieh, Chia-Ju, Pagar, Vinayak Vishnu, Weng, Chi-Chang, Xu, Hong, Graham, Thomas J. A., Lee, Virginia M.-Y., Mach, Robert H., Petersson, E. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047729/
https://www.ncbi.nlm.nih.gov/pubmed/33889379
http://dx.doi.org/10.1039/d0sc02159h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047729/
https://www.ncbi.nlm.nih.gov/pubmed/33889379
http://dx.doi.org/10.1039/d0sc02159h

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