Cargando…

Identification of Bioactive SNM1A Inhibitors

[Image: see text] SNM1A is a nuclease required to repair DNA interstrand cross-links (ICLs) caused by some anticancer compounds, including cisplatin. Unlike other nucleases involved in ICL repair, SNM1A is not needed to restore other forms of DNA damage. As such, SNM1A is an attractive target for se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buzon, Beverlee, Grainger, Ryan A., Rzadki, Cameron, Huang, Simon York Ming, Junop, Murray
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047731/ https://www.ncbi.nlm.nih.gov/pubmed/33869915 http://dx.doi.org/10.1021/acsomega.0c03528

Ejemplares similares

Structure-specific endonuclease activity of SNM1A enables processing of a DNA interstrand crosslink
por: Buzon, Beverlee, et al.
Publicado: (2018)

Pso2 (SNM1) is a DNA structure-specific endonuclease
por: Tiefenbach, Tracy, et al.
Publicado: (2012)

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases
por: Sengerová, Blanka, et al.
Publicado: (2012)

Message from SNM President
por: Mittal, BR
Publicado: (2010)

Message by President, SNM, India
por: Kumar, Rakesh
Publicado: (2019)

The SNM1A DNA repair nuclease
por: Baddock, Hannah T., et al.
Publicado: (2020)

Snm1B Interacts with PSF2
por: Stringer, Jay R., et al.
Publicado: (2012)

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo
por: Lee, Sook Y., et al.
Publicado: (2016)

Message by President Elect, SNM, India
por: Singh, Baljinder
Publicado: (2019)

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities
por: Allerston, Charles K., et al.
Publicado: (2015)

Synthesis and evaluation of squaramide and thiosquaramide inhibitors of the DNA repair enzyme SNM1A
por: Berney, Mark, et al.
Publicado: (2021)

The hSNM1 protein is a DNA 5′-exonuclease
por: Hejna, James, et al.
Publicado: (2007)

SNM1B/Apollo in the DNA damage response and telomere maintenance
por: Schmiester, Maren, et al.
Publicado: (2017)

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing
por: Iyama, Teruaki, et al.
Publicado: (2015)

Probing the Binding Requirements of Modified Nucleosides with the DNA Nuclease SNM1A
por: Dürr, Eva-Maria, et al.
Publicado: (2021)

Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport
por: Song, Shang, et al.
Publicado: (2016)

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
por: Doherty, William, et al.
Publicado: (2019)

Robust single-cell DNA methylome profiling with snmC-seq2
por: Luo, Chongyuan, et al.
Publicado: (2018)

Squaramide‐Based 5’‐Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A
por: Dürr, Eva‐Maria, et al.
Publicado: (2018)

Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features
por: Karim, Md Fazlul, et al.
Publicado: (2020)

MNM and SNM maintain but do not establish achiasmate homolog conjunction during Drosophila male meiosis
por: Sun, Michael Shoujie, et al.
Publicado: (2019)

One‐year outcomes of the ARTISAN‐SNM study with the Axonics System for the treatment of urinary urgency incontinence
por: Benson, Kevin, et al.
Publicado: (2020)

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family
por: Baddock, Hannah T, et al.
Publicado: (2021)

A Modified Semi-Nested Multiplex Malaria PCR (SnM-PCR) for the Identification of the Five Human Plasmodium Species Occurring in Southeast Asia
por: Van Hong, Nguyen, et al.
Publicado: (2013)

Two‐year outcomes of the ARTISAN‐SNM study for the treatment of urinary urgency incontinence using the Axonics rechargeable sacral neuromodulation system
por: Pezzella, Andrea, et al.
Publicado: (2021)

Identification of an XRCC1 DNA binding activity essential for retention at sites of DNA damage
por: Mok, Mac C. Y., et al.
Publicado: (2019)

Bioactivity-Guided Identification of Botanical Inhibitors of Ketohexokinase
por: Le, MyPhuong T., et al.
Publicado: (2016)

The structure of DdrB from Deinococcus: a new fold for single-stranded DNA binding proteins
por: Sugiman-Marangos, Seiji, et al.
Publicado: (2010)

Assessment of Needs in Children Suffering From Refractory Non-neurogenic Urinary and Fecal Incontinence and Their Caregivers' Needs and Attitudes Toward Alternative Therapies (SNM, TENS)
por: Dos Santos, Joana, et al.
Publicado: (2020)

Structural and phylogenetic analysis of a conserved actinobacteria-specific protein (ASP1; SCO1997) from Streptomyces coelicolor
por: Gao, Beile, et al.
Publicado: (2009)

The impact of COVID-19 on breast cancer patient consultation in a breast clinic
por: Mante, Beverlee Verona, et al.
Publicado: (2023)

Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphate
por: Jackson, Sean G, et al.
Publicado: (2007)

Parámetros gasométricos en recien nacidos normales en el Hospital General de Zona No.11 de la Ciudad de Xalapa, (1,460 Mts. S.N.M.)
por: Delfín Hierro, Rossana
Publicado: (1996)

TREATMENT, HEALTHCARE UTILIZATION AND OUTCOMES IN PATIENTS WITH GLIOBLASTOMA IN ONTARIO: A 10-YEAR COHORT STUDY
por: Rzadki, Kathryn, et al.
Publicado: (2023)

Systematic Literature Review and Meta-Analysis of Sacral Neuromodulation (SNM) in Patients with Neurogenic Lower Urinary Tract Dysfunction (nLUTD): Over 20 Years’ Experience and Future Directions
por: van Ophoven, Arndt, et al.
Publicado: (2021)

Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy
por: Jairajpuri, Deeba Shamim, et al.
Publicado: (2020)

Reputational Considerations in Firm Response to Social Issues
por: McDonald, Aaron T., et al.
Publicado: (2022)

Editorial Comment: Systematic Literature Review and Meta-Analysis of Sacral Neuromodulation (SNM) in Patients with Neurogenic Lower Urinary Tract Dysfunction (nLUTD): Over 20 Years’ Experience and Future Directions
por: Averbeck, Marcio Augusto
Publicado: (2021)

Innovative training modality for sacral neuromodulation (SNM): Patient‐specific computerized tomography (CT) reconstructed 3D‐printed training system: ICS School of Modern Technology novel training modality
por: Aydogan, Tahsin B., et al.
Publicado: (2022)

CHOREOGRAPHED EXPANSION OF SERVICES RESULTS IN DECREASED PATIENT BURDEN WITHOUT COMPROMISE OF OUTCOMES: AN ASSESSMENT OF THE ONTARIO EXPERIENCE
por: Rzadki, Kathryn, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_oqi3klnf4f3ivpb14ajnc3kir7