Late-Stage Modification of Medicine: Pd-Catalyzed Direct Synthesis and Biological Evaluation of N-Aryltacrine Derivatives

[Image: see text] A new series of N-aryltacrine derivatives were designed and synthesized as cholinesterase inhibitors by the late-stage modification of tacrine, using the palladium-catalyzed Buchwald–Hartwig cross-coupling reaction. In vitro inhibition assay against acetylcholinesterase (AChE) and...

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Detalles Bibliográficos
Autores principales: Wan, Lin-Xi, Zhen, Yong-Qi, He, Zhen-Xiang, Zhang, Yang, Zhang, Lan, Li, Xiaohuan, Gao, Feng, Zhou, Xian-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047743/
https://www.ncbi.nlm.nih.gov/pubmed/33869976
http://dx.doi.org/10.1021/acsomega.1c01404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047743/
https://www.ncbi.nlm.nih.gov/pubmed/33869976
http://dx.doi.org/10.1021/acsomega.1c01404

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