Cargando…

Lentivirus vector-mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain

Translation of promising experimental therapies from rodent models to clinical success has been complicated as the novel therapies often fail in clinical trials. Existing rodent glioma models generally do not allow for preclinical evaluation of the efficiency of novel therapies in combination with s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmad, Farizan, Hyvärinen, Anna, Pirinen, Agnieszka, Olsson, Venla, Rummukainen, Jaana, Immonen, Arto, Närväinen, Johanna, Tuunanen, Pasi, Liimatainen, Timo, Kärkkäinen, Virve, Koistinaho, Jari, Ylä-Herttuala, Seppo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047887/ https://www.ncbi.nlm.nih.gov/pubmed/33846766 http://dx.doi.org/10.3892/mmr.2021.12061

Ejemplares similares

Human Vascular Endothelial Growth Factor A(165) Expression Induces the Mouse Model of Neovascular Age-Related Macular Degeneration
por: Kokki, Emmi, et al.
Publicado: (2018)

Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance T(RAFFn), T(1ρ) and T(2) relaxation times
por: Ylä-Herttuala, Elias, et al.
Publicado: (2023)

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction
por: Vuorio, Taina, et al.
Publicado: (2018)

Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations
por: Kivelä, Antti, et al.
Publicado: (2012)

Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice
por: Merentie, Mari, et al.
Publicado: (2018)

AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice
por: Kujala, Anni, et al.
Publicado: (2022)

Quantification of myocardial infarct area based on T(RAFFn) relaxation time maps - comparison with cardiovascular magnetic resonance late gadolinium enhancement, T(1ρ) and T(2) in vivo
por: Yla-Herttuala, Elias, et al.
Publicado: (2018)

Gene Therapy Used in Cancer Treatment
por: Wirth, Thomas, et al.
Publicado: (2014)

Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?
por: Mallick, Rahul, et al.
Publicado: (2022)

Left ventricular remodeling leads to heart failure in mice with cardiac‐specific overexpression of VEGF‐B(167): echocardiography and magnetic resonance imaging study
por: Lottonen‐Raikaslehto, Line, et al.
Publicado: (2017)

Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules
por: Belt, Heini, et al.
Publicado: (2018)

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
por: Lemarchant, Sighild, et al.
Publicado: (2016)

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis
por: Lemarchant, Sighild, et al.
Publicado: (2016)

Rats Bred for Low Aerobic Capacity Become Promptly Fatigued and Have Slow Metabolic Recovery after Stimulated, Maximal Muscle Contractions
por: Torvinen, Sira, et al.
Publicado: (2012)

Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success
por: Dragneva, Galina, et al.
Publicado: (2013)

Characterization of a new IN-I-PpoI fusion protein and a homology-arm containing transgene cassette that improve transgene expression persistence and 28S rRNA gene-targeted insertion of lentiviral vectors
por: Nousiainen, Alisa, et al.
Publicado: (2023)

Short and Long-Term Effects of hVEGF-A(165) in Cre-Activated Transgenic Mice
por: Leppänen, Pia, et al.
Publicado: (2006)

Lymphangiogenic Gene Therapy With Minimal Blood Vascular Side Effects
por: Saaristo, Anne, et al.
Publicado: (2002)

A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus
por: Husso, Tiia, et al.
Publicado: (2014)

Nucleic Acid–Based Therapies for Atherosclerosis
por: Mäkinen, Petri, et al.
Publicado: (2020)

Novel RNAi-Based Therapies for Atherosclerosis
por: Ruotsalainen, Anna-Kaisa, et al.
Publicado: (2021)

Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta
por: Kiema, Miika, et al.
Publicado: (2022)

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder
por: Savchenko, Ekaterina, et al.
Publicado: (2017)

Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye
por: Koponen, Sanna, et al.
Publicado: (2021)

Epigenetic Regulation of Vascular Smooth Muscle Cell Phenotype Switching in Atherosclerotic Artery Remodeling: A Mini-Review
por: Zurek, Michelle, et al.
Publicado: (2021)

The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death
por: Tirronen, Annakaisa, et al.
Publicado: (2021)

Differential Regulation of Vascular Endothelial Growth Factors by Promoter-targeted shRNAs
por: Laham-Karam, Nihay, et al.
Publicado: (2015)

Editorial: Vascularization for Regenerative Medicine
por: Banfi, Andrea, et al.
Publicado: (2018)

Experimental Evaluation of an Interferometric Light Microscopy Particle Counter for Titering and Characterization of Virus Preparations
por: Turkki, Vesa, et al.
Publicado: (2021)

Adenoviral Gene Therapy Vectors in Clinical Use—Basic Aspects with a Special Reference to Replication-Competent Adenovirus Formation and Its Impact on Clinical Safety
por: Leikas, Aleksi J., et al.
Publicado: (2023)

Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice
por: Dijkstra, M. H., et al.
Publicado: (2014)

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation
por: Kolosowska, Natalia, et al.
Publicado: (2020)

Immunohistochemical Characterization and Sensitivity to Human Adenovirus Serotypes 3, 5, and 11p of New Cell Lines Derived from Human Diffuse Grade II to IV Gliomas
por: Niittykoski, Minna, et al.
Publicado: (2017)

Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells
por: Leinonen, Hanna M., et al.
Publicado: (2019)

Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart
por: Gallini, Radiosa, et al.
Publicado: (2016)

Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart
por: Naumenko, Nikolay, et al.
Publicado: (2017)

Critical surface exponents in 2-D 10-state Potts model
por: Kärkkäinen, L, et al.
Publicado: (1992)

Novel Designed Proteolytically Resistant VEGF-B186R127S Promotes Angiogenesis in Mouse Heart by Recruiting Endothelial Progenitor Cells
por: Mallick, Rahul, et al.
Publicado: (2022)

Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer
por: Sallinen, Hanna, et al.
Publicado: (2014)

Cervical Myelopathy Associated with Deep Neck Muscle Rhabdomyolysis after Polysubstance Abuse: A Case Report
por: Honkaniemi, Jari, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ulkua47r87q951u6qsr1863utm