Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation

Prdm12 is a key transcription factor in nociceptor neurogenesis. Mutations of Prdm12 cause congenital insensitivity to pain (CIP) from failure of nociceptor development. However, precisely how deletion of Prdm12 during development or adulthood affects nociception is unknown. Here, we employ tissue-...

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Detalles Bibliográficos
Autores principales: Landy, Mark A., Goyal, Megan, Casey, Katherine M., Liu, Chen, Lai, Helen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048104/
https://www.ncbi.nlm.nih.gov/pubmed/33789102
http://dx.doi.org/10.1016/j.celrep.2021.108913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048104/
https://www.ncbi.nlm.nih.gov/pubmed/33789102
http://dx.doi.org/10.1016/j.celrep.2021.108913

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