Lysophosphatidic acid (LPA)-antibody (504B3) engagement detected by interferometry identifies off-target binding

BACKGROUND: Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that acts through its six cognate G protein-coupled receptors. As a family, lysophospholipids have already produced medicines (e.g., sphingosine 1-phosphate) as is being pursued for LPA through the use of specific antibodies tha...

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Detalles Bibliográficos
Autores principales: Ray, Manisha, Kihara, Yasuyuki, Bornhop, Darryl J., Chun, Jerold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048308/
https://www.ncbi.nlm.nih.gov/pubmed/33853612
http://dx.doi.org/10.1186/s12944-021-01454-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048308/
https://www.ncbi.nlm.nih.gov/pubmed/33853612
http://dx.doi.org/10.1186/s12944-021-01454-4

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