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Lysophosphatidic acid (LPA)-antibody (504B3) engagement detected by interferometry identifies off-target binding

BACKGROUND: Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that acts through its six cognate G protein-coupled receptors. As a family, lysophospholipids have already produced medicines (e.g., sphingosine 1-phosphate) as is being pursued for LPA through the use of specific antibodies tha...

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Detalles Bibliográficos
Autores principales:	Ray, Manisha, Kihara, Yasuyuki, Bornhop, Darryl J., Chun, Jerold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048308/ https://www.ncbi.nlm.nih.gov/pubmed/33853612 http://dx.doi.org/10.1186/s12944-021-01454-4

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