Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils

The G protein‐coupled free fatty acid receptor 2 (FFA2R) is highly expressed on neutrophils and was previously described to regulate neutrophil activation. Allosteric targeting of G protein‐coupled receptors (GPCRs) is increasingly explored to create distinct pharmacology compared to endogenous, ort...

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Detalles Bibliográficos
Autores principales: Frei, Robert, Nordlohne, Johannes, Hüser, Ulrike, Hild, Seda, Schmidt, Johannes, Eitner, Frank, Grundmann, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Receptors, Signal Transduction, and Genes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048482/
https://www.ncbi.nlm.nih.gov/pubmed/32803826
http://dx.doi.org/10.1002/JLB.2A0720-432R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048482/
https://www.ncbi.nlm.nih.gov/pubmed/32803826
http://dx.doi.org/10.1002/JLB.2A0720-432R

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