Targeting USP13‐mediated drug tolerance increases the efficacy of EGFR inhibition of mutant EGFR in non‐small cell lung cancer

In non‐small cell lung cancer (NSCLC), activating mutations in the epidermal growth factor receptor (EGFR) induce sensitivity to EGFR tyrosine kinase inhibitors. Despite impressive clinical responses, patients ultimately relapse as a reservoir of drug‐tolerant cells persist, which ultimately leads t...

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Detalles Bibliográficos
Autores principales: Giron, Philippe, Eggermont, Carolien, Noeparast, Amir, Vandenplas, Hugo, Teugels, Erik, Forsyth, Ramses, De Wever, Olivier, Aza‐Blanc, Pedro, Gutierrez, Gustavo J., De Grève, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Molecular Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048518/
https://www.ncbi.nlm.nih.gov/pubmed/33210294
http://dx.doi.org/10.1002/ijc.33404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048518/
https://www.ncbi.nlm.nih.gov/pubmed/33210294
http://dx.doi.org/10.1002/ijc.33404

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