Phase 1 Studies to Define the Safety, Tolerability, and Pharmacokinetic and Pharmacodynamic Profiles of the Nonsteroidal Mineralocorticoid Receptor Antagonist Apararenone in Healthy Volunteers

Apararenone is a long‐acting, nonsteroidal mineralocorticoid receptor antagonist (MRA). The safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) profiles of single‐ and multiple‐dose apararenone were assessed in 3 phase 1 randomized, double‐blind studies in 223 healthy adults. Stu...

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Detalles Bibliográficos
Autores principales: Nakamura, Tadakatsu, Kawaguchi, Atsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048531/
https://www.ncbi.nlm.nih.gov/pubmed/32820619
http://dx.doi.org/10.1002/cpdd.855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048531/
https://www.ncbi.nlm.nih.gov/pubmed/32820619
http://dx.doi.org/10.1002/cpdd.855

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