Design and Synthesis of DDR1 Inhibitors with a Desired Pharmacophore Using Deep Generative Models

Discoidin domain receptor 1 (DDR1) inhibitors with a desired pharmacophore were designed using deep generative models (DGMs). DDR1 is a receptor tyrosine kinase activated by matrix collagens and implicated in diseases such as cancer, fibrosis and hypoxia. Herein we describe the synthesis and inhibit...

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Detalles Bibliográficos
Autores principales: Yoshimori, Atsushi, Asawa, Yasunobu, Kawasaki, Enzo, Tasaka, Tomohiko, Matsuda, Seiji, Sekikawa, Toru, Tanabe, Satoshi, Neya, Masahiro, Natsugari, Hideaki, Kanai, Chisato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048584/
https://www.ncbi.nlm.nih.gov/pubmed/33289306
http://dx.doi.org/10.1002/cmdc.202000786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048584/
https://www.ncbi.nlm.nih.gov/pubmed/33289306
http://dx.doi.org/10.1002/cmdc.202000786

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