Cargando…

Exposure‐Response and Population Pharmacokinetic Analyses of a Novel Subcutaneous Formulation of Daratumumab Administered to Multiple Myeloma Patients

We report the population pharmacokinetic (PK) and exposure‐response analyses of a novel subcutaneous formulation of daratumumab (DARA) using data from 3 DARA subcutaneous monotherapy studies (PAVO Part 2, MMY1008, COLUMBA) and 1 combination therapy study (PLEIADES). Results were based on 5159 PK sam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Man (Melody), Usmani, Saad Z., Mateos, Maria‐Victoria, Nahi, Hareth, Chari, Ajai, San‐Miguel, Jesus, Touzeau, Cyrille, Suzuki, Kenshi, Kaiser, Martin, Carson, Robin, Heuck, Christoph, Qi, Ming, Zhou, Honghui, Sun, Yu‐Nien, Parasrampuria, Dolly A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Exposure Response
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048619/ https://www.ncbi.nlm.nih.gov/pubmed/33145788 http://dx.doi.org/10.1002/jcph.1771

Ejemplares similares

Subcutaneous daratumumab in Asian patients with heavily pretreated multiple myeloma: subgroup analyses of the noninferiority, phase 3 COLUMBA study
por: Iida, Shinsuke, et al.
Publicado: (2021)

Exposure‐Response (Efficacy) Analysis of Daclatasvir and Asunaprevir in Japanese Patients With Hepatitis C Virus Infection
por: Ueno, Takayo, et al.
Publicado: (2018)

Evaluation of the Relationship of Glasdegib Exposure and Safety End Points in Patients With Refractory Solid Tumors and Hematologic Malignancies
por: Ruiz‐Garcia, Ana, et al.
Publicado: (2020)

Modeling the Efficacy of Natalizumab in Multiple Sclerosis Patients Who Switch From Every‐4‐Week Dosing to Extended‐Interval Dosing
por: Chang, Ih, et al.
Publicado: (2020)

Exposure‐Response Analyses for Upadacitinib Efficacy in Subjects With Atopic Dermatitis—Analyses of Phase 2b Study to Support Selection of Phase 3 Doses
por: Mohamed, Mohamed‐Eslam F., et al.
Publicado: (2020)

Subcutaneous daratumumab in patients with relapsed or refractory multiple myeloma: part 2 of the open-label, multicenter, dose-escalation phase Ib study (PAVO)
por: San-Miguel, Jesus, et al.
Publicado: (2020)

Final analysis of the phase III non-inferiority COLUMBA study of subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma
por: Usmani, Saad Z., et al.
Publicado: (2022)

Exposure
Publicado: (2020)

Subcutaneous daratumumab and hyaluronidase-fihj in newly diagnosed or relapsed/refractory multiple myeloma
por: Sanchez, Larysa, et al.
Publicado: (2021)

Daratumumab-induced transient myopic shift
por: Mavrommatis, Maria A., et al.
Publicado: (2018)

Daratumumab plus lenalidomide and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: frailty subgroup analysis of MAIA
por: Facon, Thierry, et al.
Publicado: (2022)

Daratumumab, carfilzomib, and dexamethasone in relapsed or refractory myeloma: final analysis of PLEIADES and EQUULEUS
por: Moreau, Philippe, et al.
Publicado: (2023)

Infectious complications and NK cell depletion following daratumumab treatment of Multiple Myeloma
por: Nahi, Hareth, et al.
Publicado: (2019)

Occupational noise exposure assessment using O*NET and its application to a study of hearing loss in the US general population
por: Choi, Yoon-Hyeong, et al.
Publicado: (2011)

A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the Health Effects of Arsenic Longitudinal Study (HEALS)
por: Parvez, Faruque, et al.
Publicado: (2010)

Quality of life in relation to the traffic pollution indicators NO(2) and NO(x): results from the Swedish GA(2)LEN survey
por: Sommar, Johan Nilsson, et al.
Publicado: (2014)

Exposure of hairdressers to ortho- and meta-toluidine in hair dyes
por: Johansson, Gabriella M, et al.
Publicado: (2015)

CAREX Canada: an enhanced model for assessing occupational carcinogen exposure
por: Peters, Cheryl E, et al.
Publicado: (2015)

Season and outdoor temperature in relation to detection and control of hypertension in a large rural Chinese population
por: Su, Danting, et al.
Publicado: (2014)

Pleural mesothelioma and lung cancer risks in relation to occupational history and asbestos lung burden
por: Gilham, Clare, et al.
Publicado: (2016)

Historic air pollution exposure and long-term mortality risks in England and Wales: prospective longitudinal cohort study
por: Hansell, Anna, et al.
Publicado: (2016)

Expert ratings of job demand and job control as predictors of injury and musculoskeletal disorder risk in a manufacturing cohort
por: Cantley, Linda F, et al.
Publicado: (2016)

An observational study of PM(10) and hospital admissions for acute exacerbations of chronic respiratory disease in Tasmania, Australia 1992–2002
por: Mészáros, D, et al.
Publicado: (2015)

Personal exposure to static and time-varying magnetic fields during MRI procedures in clinical practice in the UK
por: Batistatou, Evridiki, et al.
Publicado: (2016)

Cross-shift study of exposure–response relationships between bioaerosol exposure and respiratory effects in the Norwegian grain and animal feed production industry
por: Straumfors, Anne, et al.
Publicado: (2016)

Consecutive results of blood cell count and retrospective biodosimetry: useful tools of health protection regulation for radiation workers
por: Jang, Seongjae, et al.
Publicado: (2016)

Incident CTS in a large pooled cohort study: associations obtained by a Job Exposure Matrix versus associations obtained from observed exposures
por: Dale, Ann Marie, et al.
Publicado: (2018)

Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water
por: Li, Ying, et al.
Publicado: (2018)

Occupational exposure to pesticides is associated with differential DNA methylation
por: van der Plaat, Diana A, et al.
Publicado: (2018)

Neglected exposure route: cobalt on skin and its associations with urinary cobalt levels
por: Kettelarij, Jolinde, et al.
Publicado: (2018)

Cross-national comparison of two general population job exposure matrices for physical work exposures
por: Evanoff, Bradley, et al.
Publicado: (2019)

Job-exposure matrix for historical exposures to rubber dust, rubber fumes and n-Nitrosamines in the British rubber industry
por: Hidajat, Mira, et al.
Publicado: (2019)

The CONSTANCES job exposure matrix based on self-reported exposure to physical risk factors: development and evaluation
por: Evanoff, Bradley A, et al.
Publicado: (2019)

Physical work demands and psychosocial working conditions as predictors of musculoskeletal pain: a cohort study comparing self-reported and job exposure matrix measurements
por: Madsen, Ida E H, et al.
Publicado: (2018)

Classification of aerosol-generating procedures: a rapid systematic review
por: Jackson, Tanya, et al.
Publicado: (2020)

Fluorene exposure among PAH-exposed workers is associated with epigenetic markers related to lung cancer
por: Alhamdow, Ayman, et al.
Publicado: (2020)

The impact of alternative historical extrapolations of diesel exhaust exposure and radon in the Diesel Exhaust in Miners Study (DEMS)
por: Vermeulen, Roel, et al.
Publicado: (2020)

Temporal trends in respirable dust and respirable quartz concentrations within the European industrial minerals sector over a 15-year period (2002–2016)
por: Zilaout, Hicham, et al.
Publicado: (2020)

Non-communicable respiratory disease and air pollution exposure in Malawi: a prospective cohort study
por: Rylance, Sarah, et al.
Publicado: (2020)

Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans
por: Mallick, Pankajini, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_18ao42buvj2qpjsg00ekffhfrn