Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold‐Hopping Approach

Astacin metalloproteinases, in particular meprins α and β, as well as ovastacin, are emerging drug targets. Drug‐discovery efforts have led to the development of the first potent and selective inhibitors in the last few years. However, the most recent compounds are based on a highly flexible tertiar...

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, Kathrin, Jäger, Christian, Körschgen, Hagen, Geissler, Stefanie, Schlenzig, Dagmar, Buchholz, Mirko, Stöcker, Walter, Ramsbeck, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048867/
https://www.ncbi.nlm.nih.gov/pubmed/33369214
http://dx.doi.org/10.1002/cmdc.202000822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048867/
https://www.ncbi.nlm.nih.gov/pubmed/33369214
http://dx.doi.org/10.1002/cmdc.202000822

Ejemplares similares