A unique ligand‐steered strategy for CC chemokine receptor 2 homology modeling to facilitate structure‐based virtual screening

CC chemokine receptor 2 (CCR2) antagonists that disrupt CCR2/MCP‐1 interaction are expected to treat a variety of inflammatory and autoimmune diseases. The lack of CCR2 crystal structure limits the application of structure‐based drug design (SBDD) to this target. Although a few three‐dimensional the...

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Detalles Bibliográficos
Autores principales: Jin, Hongwei, Xia, Jie, Liu, Zhenming, Wang, Xiang Simon, Zhang, Liangren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048943/
https://www.ncbi.nlm.nih.gov/pubmed/33386704
http://dx.doi.org/10.1111/cbdd.13820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048943/
https://www.ncbi.nlm.nih.gov/pubmed/33386704
http://dx.doi.org/10.1111/cbdd.13820

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