The tale of proteolysis targeting chimeras (PROTACs) for Leucine‐Rich Repeat Kinase 2 (LRRK2)

Here we present the rational design and synthetic methodologies towards proteolysis‐targeting chimeras (PROTACs) for the recently‐emerged target leucine‐rich repeat kinase 2 (LRRK2). Two highly potent, selective, brain‐penetrating kinase inhibitors were selected, and their structure was appropriatel...

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Detalles Bibliográficos
Autores principales: Konstantinidou, Markella, Oun, Asmaa, Pathak, Pragya, Zhang, Bidong, Wang, Zefeng, ter Brake, Frans, Dolga, Amalia M., Kortholt, Arjan, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048960/
https://www.ncbi.nlm.nih.gov/pubmed/33278061
http://dx.doi.org/10.1002/cmdc.202000872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048960/
https://www.ncbi.nlm.nih.gov/pubmed/33278061
http://dx.doi.org/10.1002/cmdc.202000872

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