Monomeric a-synuclein (aS) inhibits amyloidogenesis of human prion protein (hPrP) by forming a stable aS-hPrP hetero-dimer.

Intermolecular interaction between hPrP and αS was investigated using high-speed atomic force microscopy, dynamic light scattering, and nuclear magnetic resonance. We found that hPrP spontaneously gathered and naturally formed oligomers. Upon addition of monomer αS with a disordered conformation, po...

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Detalles Bibliográficos
Autores principales: Yamashita, Satoshi, O. Kamatari, Yuji, Honda, Ryo, Niwa, Ayumi, Tomiata, Hiroyuki, Hara, Akira, Kuwata, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Short Communicatios
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049198/
https://www.ncbi.nlm.nih.gov/pubmed/33849375
http://dx.doi.org/10.1080/19336896.2021.1910176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049198/
https://www.ncbi.nlm.nih.gov/pubmed/33849375
http://dx.doi.org/10.1080/19336896.2021.1910176

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