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ORN: Inferring patient-specific dysregulation status of pathway modules in cancer with OR-gate Network

Pathway level understanding of cancer plays a key role in precision oncology. However, the current amount of high-throughput data cannot support the elucidation of full pathway topology. In this study, instead of directly learning the pathway network, we adapted the probabilistic OR gate to model th...

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Detalles Bibliográficos
Autores principales: Liang, Lifan, Zhu, Kunju, Tao, Junyan, Lu, Songjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049496/
https://www.ncbi.nlm.nih.gov/pubmed/33819263
http://dx.doi.org/10.1371/journal.pcbi.1008792