Cargando…

miRNA-221 Regulates Spinal Cord Injury-Induced Inflammatory Response through Targeting TNF-α Expression

OBJECTIVES: To investigate the roles of miR-221 in spinal cord injury (SCI) as well as the underlying mechanism. METHODS: A mouse model of SCI was generated and used to examine dynamic changes in grip strength of the mouse upper and lower limbs. The expression of miR-221 and tumor necrosis factor-α...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Feng, Zhang, Haiwei, Huang, Tianwen, Shi, Jianhui, Wei, Tianli, Wang, Yansong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049790/ https://www.ncbi.nlm.nih.gov/pubmed/33928162 http://dx.doi.org/10.1155/2021/6687963

Ejemplares similares

S100A9 blockade improves the functional recovery after spinal cord injury via mediating neutrophil infiltration
por: Sun, Feng, et al.
Publicado: (2022)

Astragalin Protects against Spinal Cord Ischemia Reperfusion Injury through Attenuating Oxidative Stress-Induced Necroptosis
por: Sun, Feng, et al.
Publicado: (2021)

Correlation between miRNA-124, miRNA-544a, and TNF-α levels in acute spinal cord injury
por: Ma, Xiaomin, et al.
Publicado: (2022)

Emerging Exosomes and Exosomal MiRNAs in Spinal Cord Injury
por: Feng, Jia, et al.
Publicado: (2021)

miRNA-221 and miRNA-222 synergistically function to promote vascular calcification
por: Mackenzie, N C W, et al.
Publicado: (2014)

Roles of miRNAs in spinal cord injury and potential therapeutic interventions
por: Almurshidi, Badria, et al.
Publicado: (2019)

Identification of targets of miRNA-221 and miRNA-222 in fulvestrant-resistant breast cancer
por: Liu, Pengfei, et al.
Publicado: (2016)

The Importance of Using Exosome-Loaded miRNA for the Treatment of Spinal Cord Injury
por: Shen, Yunpeng, et al.
Publicado: (2022)

Bioinformatics analysis of circulating miRNAs related to cancer following spinal cord injury
por: Lopes, Elisangela C.P., et al.
Publicado: (2019)

Genes and miRNAs as Hurdles and Promoters of Corticospinal Tract Regeneration in Spinal Cord Injury
por: Boido, Marina, et al.
Publicado: (2021)

MiRNAs as Promising Translational Strategies for Neuronal Repair and Regeneration in Spinal Cord Injury
por: Silvestro, Serena, et al.
Publicado: (2022)

miRNA-221 promotes cutaneous squamous cell carcinoma progression by targeting PTEN
por: Gong, Zhen-Hua, et al.
Publicado: (2019)

The Role of miRNA-221 and miRNA-34a in Non-Melanoma Skin Cancer of the Head and Neck Region
por: Tamas, Tiberiu, et al.
Publicado: (2023)

MiRNA-221 from tissue may predict the prognosis of patients with osteosarcoma
por: Gong, Ningji, et al.
Publicado: (2018)

CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-α in Postmenopausal Osteoporosis
por: Liu, Zhuochao, et al.
Publicado: (2020)

Acute Spinal Cord Injury: A Systematic Review Investigating miRNA Families Involved
por: Pinchi, Enrica, et al.
Publicado: (2019)

Oncomirs miRNA-221/222 and Tumor Suppressors miRNA-199a/195 Are Crucial miRNAs in Liver Cancer: A Systematic Analysis
por: Li, Yanhu, et al.
Publicado: (2016)

Delivery of Anti-miRNA-221 for Colorectal Carcinoma Therapy Using Modified Cord Blood Mesenchymal Stem Cells-Derived Exosomes
por: Han, Siqi, et al.
Publicado: (2021)

Signaling Modulation by miRNA-221-3p During Tooth Morphogenesis in Mice
por: Aryal, Yam Prasad, et al.
Publicado: (2021)

The Effect of miRNA-Modified Exosomes in Animal Models of Spinal Cord Injury: A meta-Analysis
por: Hu, Mengdie, et al.
Publicado: (2022)

MSC derived EV loaded with miRNA‐22 inhibits the inflammatory response and nerve function recovery after spinal cord injury in rats
por: Sheng, Yongjia, et al.
Publicado: (2021)

Related Fluoxetine and Methylprednisolone Changes of TNF-α and IL-6 Expression in The Hypothyroidism Rat Model of Spinal Cord Injury
por: Zirak, Atousa, et al.
Publicado: (2021)

Spinal cord injury dysregulates fibro-adipogenic progenitors miRNAs signaling to promote neurogenic heterotopic ossifications
por: Gueguen, Jules, et al.
Publicado: (2023)

miR-328-3p mediates the anti-tumor effect in osteosarcoma via directly targeting MMP-16
por: Shi, Jianhui, et al.
Publicado: (2019)

EGFR signaling pathway and related-miRNAs in age-related diseases: the example of miR-221 and miR-222
por: Teixeira, Ana L., et al.
Publicado: (2012)

Ultrashortwave radiation promotes the recovery of spinal cord injury by inhibiting inflammation via suppression of the MK2/TNF-α pathway
por: Wang, Nan, et al.
Publicado: (2018)

Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-α
por: Meerson, A., et al.
Publicado: (2013)

The role of aberrant expression of T cell miRNAs affected by TNF-α in the immunopathogenesis of rheumatoid arthritis
por: Lai, Ning-Sheng, et al.
Publicado: (2017)

miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6
por: Oglesby, Irene K, et al.
Publicado: (2015)

MiRNA-181a Regulates Adipogenesis by Targeting Tumor Necrosis Factor-α (TNF-α) in the Porcine Model
por: Li, Hongyi, et al.
Publicado: (2013)

Simultaneous Visualization of MiRNA-221 and Caspase-3 in Cancer Cells for Investigating the Feasibility of MiRNA-Targeted Therapy with a Dual-Color Fluorescent Nanosensor
por: Ren, Mingyao, et al.
Publicado: (2022)

Identification of miRNA-mRNA Pairs in Relation to TNF-α/IL-1β Induced Inflammatory Response in Intervertebral Disc Degeneration
por: Wei, Ye, et al.
Publicado: (2022)

Down-Regulation of miRNA-128 Contributes to Neuropathic Pain Following Spinal Cord Injury via Activation of P38
por: Yang, Zhaoyun, et al.
Publicado: (2017)

Exosomes secreted from miRNA-29b-modified mesenchymal stem cells repaired spinal cord injury in rats
por: Yu, Tao, et al.
Publicado: (2019)

miR-221 suppression through nanoparticle-based miRNA delivery system for hepatocellular carcinoma therapy and its diagnosis as a potential biomarker
por: Li, Feng, et al.
Publicado: (2018)

Upregulation of miR-128 inhibits neuronal cell apoptosis following spinal cord injury via FasL downregulation by repressing ULK1
por: Liu, Ruixuan, et al.
Publicado: (2021)

An anti-inflammatory and neuroprotective biomimetic nanoplatform for repairing spinal cord injury
por: Gao, Xiang, et al.
Publicado: (2022)

Circulating miRNAs in girls with abdominal obesity: miR‐221‐3p as a biomarker of response to weight loss interventions
por: Ojeda‐Rodríguez, Ana, et al.
Publicado: (2022)

Retracted: Identification of miRNA-mRNA Pairs in Relation to TNF-α/IL-1β Induced Inflammatory Response in Intervertebral Disc Degeneration
por: and Alternative Medicine, Evidence-Based Complementary
Publicado: (2023)

Long Noncoding RNA SOCS2-AS Promotes Leukemogenesis in FLT3-ITD+ Acute Myeloid Leukemia Through miRNA-221
por: Zhang, Rong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pdlh6faet9a067t8unhhka9opo