Non-functioning adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy that arises from the adrenal cortex and can be classified as either non-functioning or functioning. A patient with non-functioning ACC may present no specific symptoms. Imaging analysis can provide some information to a clinician who suspects ACC,...

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Autores principales: Lenh, Bui-Van, Duc, Nguyen Minh, Tra My, Thieu-Thi, Minh, Tran Ngoc, Bang, Luong Viet, Linh, Le Tuan, Giang, Bui-Van, Thong, Pham Minh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049877/
https://www.ncbi.nlm.nih.gov/pubmed/33889224
http://dx.doi.org/10.1016/j.radcr.2021.03.006
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author Lenh, Bui-Van
Duc, Nguyen Minh
Tra My, Thieu-Thi
Minh, Tran Ngoc
Bang, Luong Viet
Linh, Le Tuan
Giang, Bui-Van
Thong, Pham Minh
author_facet Lenh, Bui-Van
Duc, Nguyen Minh
Tra My, Thieu-Thi
Minh, Tran Ngoc
Bang, Luong Viet
Linh, Le Tuan
Giang, Bui-Van
Thong, Pham Minh
author_sort Lenh, Bui-Van
collection PubMed
description Adrenocortical carcinoma (ACC) is a rare malignancy that arises from the adrenal cortex and can be classified as either non-functioning or functioning. A patient with non-functioning ACC may present no specific symptoms. Imaging analysis can provide some information to a clinician who suspects ACC, such as tumor size, density, washout, necrosis, hemorrhage, and calcification. Histopathology is used to confirm and determine the origin of the malignancy and can provide relevant prognostic information. Microscopic findings can be used to obtain information such as the Weiss score, resection surface features, Ki-67 proliferative index, and the degree of capsular and vascular invasion. Surgery can be curative for localized tumors, and adjuvant therapy using mitotane and cytotoxic chemotherapy is often employed for advanced-stage tumors. We describe a case report of a 32-year-old man with a non-functioning ACC that highlights the importance of radiological and pathological features in the diagnosis of ACC and their use as prognostic factors.
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spelling pubmed-80498772021-04-21 Non-functioning adrenocortical carcinoma Lenh, Bui-Van Duc, Nguyen Minh Tra My, Thieu-Thi Minh, Tran Ngoc Bang, Luong Viet Linh, Le Tuan Giang, Bui-Van Thong, Pham Minh Radiol Case Rep Case Report Adrenocortical carcinoma (ACC) is a rare malignancy that arises from the adrenal cortex and can be classified as either non-functioning or functioning. A patient with non-functioning ACC may present no specific symptoms. Imaging analysis can provide some information to a clinician who suspects ACC, such as tumor size, density, washout, necrosis, hemorrhage, and calcification. Histopathology is used to confirm and determine the origin of the malignancy and can provide relevant prognostic information. Microscopic findings can be used to obtain information such as the Weiss score, resection surface features, Ki-67 proliferative index, and the degree of capsular and vascular invasion. Surgery can be curative for localized tumors, and adjuvant therapy using mitotane and cytotoxic chemotherapy is often employed for advanced-stage tumors. We describe a case report of a 32-year-old man with a non-functioning ACC that highlights the importance of radiological and pathological features in the diagnosis of ACC and their use as prognostic factors. Elsevier 2021-04-03 /pmc/articles/PMC8049877/ /pubmed/33889224 http://dx.doi.org/10.1016/j.radcr.2021.03.006 Text en © 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Lenh, Bui-Van
Duc, Nguyen Minh
Tra My, Thieu-Thi
Minh, Tran Ngoc
Bang, Luong Viet
Linh, Le Tuan
Giang, Bui-Van
Thong, Pham Minh
Non-functioning adrenocortical carcinoma
title Non-functioning adrenocortical carcinoma
title_full Non-functioning adrenocortical carcinoma
title_fullStr Non-functioning adrenocortical carcinoma
title_full_unstemmed Non-functioning adrenocortical carcinoma
title_short Non-functioning adrenocortical carcinoma
title_sort non-functioning adrenocortical carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049877/
https://www.ncbi.nlm.nih.gov/pubmed/33889224
http://dx.doi.org/10.1016/j.radcr.2021.03.006
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