Non-functioning adrenocortical carcinoma
Adrenocortical carcinoma (ACC) is a rare malignancy that arises from the adrenal cortex and can be classified as either non-functioning or functioning. A patient with non-functioning ACC may present no specific symptoms. Imaging analysis can provide some information to a clinician who suspects ACC,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049877/ https://www.ncbi.nlm.nih.gov/pubmed/33889224 http://dx.doi.org/10.1016/j.radcr.2021.03.006 |
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author | Lenh, Bui-Van Duc, Nguyen Minh Tra My, Thieu-Thi Minh, Tran Ngoc Bang, Luong Viet Linh, Le Tuan Giang, Bui-Van Thong, Pham Minh |
author_facet | Lenh, Bui-Van Duc, Nguyen Minh Tra My, Thieu-Thi Minh, Tran Ngoc Bang, Luong Viet Linh, Le Tuan Giang, Bui-Van Thong, Pham Minh |
author_sort | Lenh, Bui-Van |
collection | PubMed |
description | Adrenocortical carcinoma (ACC) is a rare malignancy that arises from the adrenal cortex and can be classified as either non-functioning or functioning. A patient with non-functioning ACC may present no specific symptoms. Imaging analysis can provide some information to a clinician who suspects ACC, such as tumor size, density, washout, necrosis, hemorrhage, and calcification. Histopathology is used to confirm and determine the origin of the malignancy and can provide relevant prognostic information. Microscopic findings can be used to obtain information such as the Weiss score, resection surface features, Ki-67 proliferative index, and the degree of capsular and vascular invasion. Surgery can be curative for localized tumors, and adjuvant therapy using mitotane and cytotoxic chemotherapy is often employed for advanced-stage tumors. We describe a case report of a 32-year-old man with a non-functioning ACC that highlights the importance of radiological and pathological features in the diagnosis of ACC and their use as prognostic factors. |
format | Online Article Text |
id | pubmed-8049877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-80498772021-04-21 Non-functioning adrenocortical carcinoma Lenh, Bui-Van Duc, Nguyen Minh Tra My, Thieu-Thi Minh, Tran Ngoc Bang, Luong Viet Linh, Le Tuan Giang, Bui-Van Thong, Pham Minh Radiol Case Rep Case Report Adrenocortical carcinoma (ACC) is a rare malignancy that arises from the adrenal cortex and can be classified as either non-functioning or functioning. A patient with non-functioning ACC may present no specific symptoms. Imaging analysis can provide some information to a clinician who suspects ACC, such as tumor size, density, washout, necrosis, hemorrhage, and calcification. Histopathology is used to confirm and determine the origin of the malignancy and can provide relevant prognostic information. Microscopic findings can be used to obtain information such as the Weiss score, resection surface features, Ki-67 proliferative index, and the degree of capsular and vascular invasion. Surgery can be curative for localized tumors, and adjuvant therapy using mitotane and cytotoxic chemotherapy is often employed for advanced-stage tumors. We describe a case report of a 32-year-old man with a non-functioning ACC that highlights the importance of radiological and pathological features in the diagnosis of ACC and their use as prognostic factors. Elsevier 2021-04-03 /pmc/articles/PMC8049877/ /pubmed/33889224 http://dx.doi.org/10.1016/j.radcr.2021.03.006 Text en © 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Lenh, Bui-Van Duc, Nguyen Minh Tra My, Thieu-Thi Minh, Tran Ngoc Bang, Luong Viet Linh, Le Tuan Giang, Bui-Van Thong, Pham Minh Non-functioning adrenocortical carcinoma |
title | Non-functioning adrenocortical carcinoma |
title_full | Non-functioning adrenocortical carcinoma |
title_fullStr | Non-functioning adrenocortical carcinoma |
title_full_unstemmed | Non-functioning adrenocortical carcinoma |
title_short | Non-functioning adrenocortical carcinoma |
title_sort | non-functioning adrenocortical carcinoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049877/ https://www.ncbi.nlm.nih.gov/pubmed/33889224 http://dx.doi.org/10.1016/j.radcr.2021.03.006 |
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