Soluble αKlotho downregulates Orai1-mediated store-operated Ca(2+) entry via PI3K-dependent signaling

αKlotho is a type 1 transmembrane anti-aging protein. αKlotho-deficient mice have premature aging phenotypes and an imbalance of ion homeostasis including Ca(2+) and phosphate. Soluble αKlotho is known to regulate multiple ion channels and growth factor-mediated phosphoinositide-3-kinase (PI3K) sign...

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Detalles Bibliográficos
Autores principales: Kim, Ji-Hee, Park, Eun Young, Hwang, Kyu-Hee, Park, Kyu-Sang, Choi, Seong Jin, Cha, Seung-Kuy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Ion Channels, Receptors and Transporters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049930/
https://www.ncbi.nlm.nih.gov/pubmed/33386992
http://dx.doi.org/10.1007/s00424-020-02510-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049930/
https://www.ncbi.nlm.nih.gov/pubmed/33386992
http://dx.doi.org/10.1007/s00424-020-02510-1

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