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The melanocortin pathway and energy homeostasis: From discovery to obesity therapy
BACKGROUND: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more subtle polymorphic variations influencing the pop...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050006/ https://www.ncbi.nlm.nih.gov/pubmed/33684608 http://dx.doi.org/10.1016/j.molmet.2021.101206 |