Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor

The epidermal growth factor receptor (EGFR) is the most intensively investigated receptor tyrosine kinase. Several EGFR mutations and modifications have been shown to lead to abnormal self-activation, which plays a critical role in carcinogenesis. Environmental air pollutants, which are associated w...

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Detalles Bibliográficos
Autores principales: Nakahara, Kengo, Hamada, Kyohei, Tsuchida, Tomoki, Takasugi, Nobumasa, Abiko, Yumi, Shien, Kazuhiko, Toyooka, Shinichi, Kumagai, Yoshito, Uehara, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050034/
https://www.ncbi.nlm.nih.gov/pubmed/33705793
http://dx.doi.org/10.1016/j.jbc.2021.100524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050034/
https://www.ncbi.nlm.nih.gov/pubmed/33705793
http://dx.doi.org/10.1016/j.jbc.2021.100524

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