Cargando…

Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor

The epidermal growth factor receptor (EGFR) is the most intensively investigated receptor tyrosine kinase. Several EGFR mutations and modifications have been shown to lead to abnormal self-activation, which plays a critical role in carcinogenesis. Environmental air pollutants, which are associated w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakahara, Kengo, Hamada, Kyohei, Tsuchida, Tomoki, Takasugi, Nobumasa, Abiko, Yumi, Shien, Kazuhiko, Toyooka, Shinichi, Kumagai, Yoshito, Uehara, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050034/ https://www.ncbi.nlm.nih.gov/pubmed/33705793 http://dx.doi.org/10.1016/j.jbc.2021.100524

Ejemplares similares

Polysulfide Na(2)S(4) regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts
por: Abiko, Yumi, et al.
Publicado: (2017)

Generation of Aryl Radicals from Aryl Hydrazines via Catalytic Iodine in Air: Arylation of Substituted 1,4-Naphthoquinones
por: Sar, Saibal, et al.
Publicado: (2020)

The Cellular and Molecular Determinants of Naphthoquinone-Dependent Activation of the Aryl Hydrocarbon Receptor
por: Faber, Samantha C., et al.
Publicado: (2020)

Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain
por: Nomura, Ryosuke, et al.
Publicado: (2022)

The Emerging Role of Electrophiles as a Key Regulator for Endoplasmic Reticulum (ER) Stress
por: Takasugi, Nobumasa, et al.
Publicado: (2019)

Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases—Studies on Inhibition Mechanism and Kinetics
por: Klein, Philipp, et al.
Publicado: (2020)

ASO Author Reflections: Prognostic Impact of the Primary Tumor Resection for Lung Cancer Patients Diagnosed with Pleural Dissemination in the Perioperative Period—Importance of Biomarker-Based Treatment Decision Making
por: Shien, Kazuhiko, et al.
Publicado: (2023)

Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells
por: Unoki, Takamitsu, et al.
Publicado: (2016)

Robotic Mediastinal Tumor Resections: Position and Port Placement
por: Okazaki, Mikio, et al.
Publicado: (2022)

The fate of methylmercury through the formation of bismethylmercury sulfide as an intermediate in mice
por: Abiko, Yumi, et al.
Publicado: (2021)

Redox toxicology of environmental chemicals causing oxidative stress
por: Zheng, Fuli, et al.
Publicado: (2020)

How Substitution Combines with Non-Covalent Interactions to Modulate 1,4-Naphthoquinone and Its Derivatives Molecular Features—Multifactor Studies
por: Pocheć, Michał, et al.
Publicado: (2021)

The Trypanocidal Activity of Naphthoquinones: A Review
por: Ventura Pinto, Antônio, et al.
Publicado: (2009)

The diverse mechanisms and anticancer potential of naphthoquinones
por: Pereyra, Carolina Escardó, et al.
Publicado: (2019)

Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase
por: Bolding, Julie E., et al.
Publicado: (2022)

Regulatory Mechanism of the IL-33–IL-37 Axis via Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis
por: Tsuji, Gaku, et al.
Publicado: (2023)

Variations in product in reactions of naphthoquinone with primary amines
por: Singh, Marjit W, et al.
Publicado: (2007)

Modification of Phospholipid Bilayers Induced by Sulfurated Naphthoquinones
por: Di Vitta, Claudio, et al.
Publicado: (2013)

Monasone Naphthoquinone Biosynthesis and Resistance in Monascus Fungi
por: Li, Mu, et al.
Publicado: (2020)

Design, synthesis and anticancer activity of naphthoquinone derivatives
por: Shen, Xiao-bao, et al.
Publicado: (2020)

The Pursuit of the “Inside” of the Amyloid Hypothesis—Is C99 a Promising Therapeutic Target for Alzheimer’s Disease?
por: Takasugi, Nobumasa, et al.
Publicado: (2023)

Robot-assisted thoracoscopic lobectomy for severe incomplete interlober fissure
por: Okazaki, Mikio, et al.
Publicado: (2021)

Formation of 5-Hydroxy-3-methoxy-1,4-naphthoquinone and 8-Hydroxy-4-methoxy-1,2-naphthoquinone from Juglone
por: Blauenburg, Bastian, et al.
Publicado: (2012)

Computational and Crystallographic Examination of Naphthoquinone Based Diarylethene Photochromes
por: Patel, Dinesh G., et al.
Publicado: (2020)

Antiviral Potential of Naphthoquinones Derivatives Encapsulated within Liposomes
por: Giongo, Viveca, et al.
Publicado: (2021)

Exploring the Antimicrobial and Antitumoral Activities of Naphthoquinone-Grafted Chitosans
por: Pauli, Fernanda Petzold, et al.
Publicado: (2023)

Competition between In-Plane vs Above-Plane Configurations of Water with Aromatic Molecules: Non-Covalent Interactions in 1,4-Naphthoquinone-(H(2)O)(1–3) Complexes
por: Baweja, Shefali, et al.
Publicado: (2022)

Induction Chemoradiotherapy Followed by Surgical Resection for Clinical T3 or T4 Locally Advanced Non–Small Cell Lung Cancer
por: Shien, Kazuhiko, et al.
Publicado: (2012)

Isolation and characterization of a covalent Ce(IV)-Aryl complex with an anomalous (13)C chemical shift
por: Panetti, Grace B., et al.
Publicado: (2021)

Mega Base Map of the Epidermal Growth Factor (EGF) Receptor Gene Flanking Regions and Structure of the Amplification Units in EGF Receptor‐hyperproducing Squamous Carcinoma Cells
por: Kawasaki, Kazuhiko, et al.
Publicado: (1988)

Cytotoxicity Mechanism of Two Naphthoquinones (Menadione and Plumbagin) in Saccharomyces cerevisiae
por: Castro, Frederico Augusto Vieira, et al.
Publicado: (2008)

5-Hydroxy-8-nitro-1,4-naphthoquinone
por: Tan, Daniel Teoh-Chuan, et al.
Publicado: (2008)

In Vitro Induction of Erythrocyte Phosphatidylserine Translocation by the Natural Naphthoquinone Shikonin
por: Lupescu, Adrian, et al.
Publicado: (2014)

Naphthoquinone glycosides for bioelectroanalytical enumeration of the faecal indicator Escherichia coli
por: Hinks, Jamie, et al.
Publicado: (2016)

Naphthoquinone Derivatives as Scaffold to Develop New Drugs for Tuberculosis Treatment
por: Halicki, Priscila C. B., et al.
Publicado: (2018)

Cytotoxic and antibacterial naphthoquinones from an endophytic fungus, Cladosporium sp.
por: Khan, Md. Imdadul Huque, et al.
Publicado: (2016)

Description of a Naphthoquinonic Crystal Produced by the Fungus Scytalidium cuboideum
por: Gutierrez, Sarath M. Vega, et al.
Publicado: (2018)

Comparative In Vitro Toxicology of Novel Cytoprotective Short-Chain Naphthoquinones
por: Feng, Zikai, et al.
Publicado: (2020)

Metabolic Stability of New Mito-Protective Short-Chain Naphthoquinones
por: Feng, Zikai, et al.
Publicado: (2020)

Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer’s Disease
por: Campora, Marta, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_knptai713qljid7javo4bdh5h6