Tadalafil ameliorates bladder overactivity by restoring insulin-activated detrusor relaxation via the bladder mucosal IRS/PI3K/AKT/eNOS pathway in fructose-fed rats

The pathophysiologies of metabolic syndrome (MS) and overactive bladder (OAB) might overlap. Using fructose-fed rats (FFRs) as a rodent model of MS we investigated the effects of tadalafil (a phosphodiesterase type 5 inhibitor) on the dysregulated insulin signalling in the bladder mucosa and bladder...

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Detalles Bibliográficos
Autores principales: Lee, Wei-Chia, Leu, Steve, Wu, Kay L. H., Tain, You-Lin, Chuang, Yao-Chi, Chan, Julie Y. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050041/
https://www.ncbi.nlm.nih.gov/pubmed/33859259
http://dx.doi.org/10.1038/s41598-021-87505-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050041/
https://www.ncbi.nlm.nih.gov/pubmed/33859259
http://dx.doi.org/10.1038/s41598-021-87505-3

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