A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models

E26 avian leukemia oncogene 2, 3′ domain (Ets2) has been implicated in various biological processes. An Ets2 mutant model (Ets2(db1/db1)), which lacks the DNA-binding domain, was previously reported to exhibit embryonic lethality caused by a trophoblast abnormality. This phenotype could be rescued b...

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Detalles Bibliográficos
Autores principales: Kishimoto, Yuki, Nishiura, Iori, Hirata, Wataru, Yuri, Shunsuke, Yamamoto, Nami, Ikawa, Masahito, Isotani, Ayako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050053/
https://www.ncbi.nlm.nih.gov/pubmed/33859300
http://dx.doi.org/10.1038/s41598-021-87751-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050053/
https://www.ncbi.nlm.nih.gov/pubmed/33859300
http://dx.doi.org/10.1038/s41598-021-87751-5

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