Cargando…

A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models

E26 avian leukemia oncogene 2, 3′ domain (Ets2) has been implicated in various biological processes. An Ets2 mutant model (Ets2(db1/db1)), which lacks the DNA-binding domain, was previously reported to exhibit embryonic lethality caused by a trophoblast abnormality. This phenotype could be rescued b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kishimoto, Yuki, Nishiura, Iori, Hirata, Wataru, Yuri, Shunsuke, Yamamoto, Nami, Ikawa, Masahito, Isotani, Ayako
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050053/ https://www.ncbi.nlm.nih.gov/pubmed/33859300 http://dx.doi.org/10.1038/s41598-021-87751-5

Ejemplares similares

Generation of the Y-chromosome linked red fluorescent protein transgenic mouse model and sexing at the preimplantation stage
por: Hirata, Wataru, et al.
Publicado: (2021)

Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA
por: Mashiko, Daisuke, et al.
Publicado: (2013)

Generation of Hprt-disrupted rat through mouse←rat ES chimeras
por: Isotani, Ayako, et al.
Publicado: (2016)

Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats
por: Matsumura, Takafumi, et al.
Publicado: (2022)

An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility
por: MATSUMURA, Takafumi, et al.
Publicado: (2019)

Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice(†)
por: Oji, Asami, et al.
Publicado: (2020)

Intergenerational effect of short-term spaceflight in mice
por: Yoshida, Keisuke, et al.
Publicado: (2021)

Chimeric analysis with newly established EGFP/DsRed2-tagged ES cells identify HYDIN as essential for spermiogenesis in mice
por: Oura, Seiya, et al.
Publicado: (2018)

Male mice, caged in the International Space Station for 35 days, sire healthy offspring
por: Matsumura, Takafumi, et al.
Publicado: (2019)

Duchenne muscular dystrophy caused by a frame-shift mutation in the acceptor splice site of intron 26
por: Meregalli, Mirella, et al.
Publicado: (2016)

CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice
por: Oji, Asami, et al.
Publicado: (2016)

Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice
por: Oura, Seiya, et al.
Publicado: (2022)

SHIFT: Server for hidden stops analysis in frame-shifted translation
por: Gupta, Arun, et al.
Publicado: (2013)

Scheduled simple production method of pseudopregnant female mice for embryo transfer using the luteinizing hormone-releasing hormone agonist
por: Sari, Gema Puspa, et al.
Publicado: (2022)

Frame shift mutations as a novel mechanism for the generation of neutralization resistant mutants of human respiratory syncytial virus.
por: García-Barreno, B, et al.
Publicado: (1990)

CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis
por: Young, Samantha A. M., et al.
Publicado: (2015)

One-step generation of multiple transgenic mouse lines using an improved Pronuclear Injection-based Targeted Transgenesis (i-PITT)
por: Ohtsuka, Masato, et al.
Publicado: (2015)

Calreticulin is required for development of the cumulus oocyte complex and female fertility
por: Tokuhiro, Keizo, et al.
Publicado: (2015)

Defective Glycinergic Synaptic Transmission in Zebrafish Motility Mutants
por: Hirata, Hiromi, et al.
Publicado: (2010)

Functional analysis of a frame-shift mutant of the dihydropyridine receptor pore subunit (α(1S)) expressing two complementary protein fragments
por: Ahern, Chris A, et al.
Publicado: (2001)

Electrical stimulation mitigates muscle degradation shift in gene expressions during 12-h mechanical ventilation
por: Nakai, Hideki, et al.
Publicado: (2023)

Gene refashioning through innovative shifting of reading frames in mosses
por: Guan, Yanlong, et al.
Publicado: (2018)

RNA-binding protein Ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with Nanos3
por: SENOO, Manami, et al.
Publicado: (2020)

The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum
por: Miyata, Haruhiko, et al.
Publicado: (2021)

Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection
por: Baba, Tomoya, et al.
Publicado: (2006)

Introducing COCOS: codon consequence scanner for annotating reading frame changes induced by stop-lost and frame shift variants
por: Butkiewicz, Mariusz, et al.
Publicado: (2017)

In-Frame and Frame-Shift Editing of the Ehd1 Gene to Develop Japonica Rice With Prolonged Basic Vegetative Growth Periods
por: Wu, Mingji, et al.
Publicado: (2020)

Rhetorical Framing and Needle Exchange in Rural Indiana: Shifting Perspectives and Policy
por: Murphy, Ryan M.
Publicado: (2019)

Frame-shifted proteins of a given gene retain the same function
por: Huang, Xin, et al.
Publicado: (2020)

A Frame-Shift for IGF-1R in Breast Cancer and Metastasis
por: Obr, Alison E, et al.
Publicado: (2021)

The challenge of framing for efforts to mitigate the risks of “dual use” research in the life sciences
por: Husbands, Jo L.
Publicado: (2018)

Frame disruptions in human mRNA transcripts, and their relationship with splicing and protein structures
por: Harrison, Paul, et al.
Publicado: (2007)

slORFfinder: a tool to detect open reading frames resulting from trans-splicing of spliced leader sequences
por: Song, Bo, et al.
Publicado: (2023)

The Immature Fiber Mutant Phenotype of Cotton (Gossypium hirsutum) Is Linked to a 22-bp Frame-Shift Deletion in a Mitochondria Targeted Pentatricopeptide Repeat Gene
por: Thyssen, Gregory N., et al.
Publicado: (2016)

Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology
por: Pillmann, Holger, et al.
Publicado: (2011)

An efficient ribosomal frame-shifting signal in the polymerase-encoding region of the coronavirus IBV.
por: Brierley, I, et al.
Publicado: (1987)

Hunting Down Frame Shifts: Ecological Analysis of Diverse Functional Gene Sequences
por: Strejcek, Michal, et al.
Publicado: (2015)

A nucleotide deletion and frame-shift cause analbuminemia in a Turkish family
por: Caridi, Gianluca, et al.
Publicado: (2016)

Frame-shifted proteins of a given gene are unlikely to retain the same function
por: Mankin, Alexander S.
Publicado: (2020)

Topic Modeling Uncovers Shifts in Media Framing of the German Renewable Energy Act
por: Dehler-Holland, Joris, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_q3d1mdq5cprdrkjgp8rdek72j4