New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D(2) receptor regulation and signaling

The dopamine D(2) receptor (D(2)R) is the target of drugs used to treat the symptoms of Parkinson’s disease and schizophrenia. The D(2)R is regulated through its interaction with and phosphorylation by G protein receptor kinases (GRKs) and interaction with arrestins. More recently, D(2)R arrestin-me...

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Detalles Bibliográficos
Autores principales: Mann, Anika, Keen, Alastair C., Mark, Hanka, Dasgupta, Pooja, Javitch, Jonathan A., Canals, Meritxell, Schulz, Stefan, Robert Lane, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050214/
https://www.ncbi.nlm.nih.gov/pubmed/33859231
http://dx.doi.org/10.1038/s41598-021-87417-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050214/
https://www.ncbi.nlm.nih.gov/pubmed/33859231
http://dx.doi.org/10.1038/s41598-021-87417-2

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