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Proteomic investigation of Cbl and Cbl-b in neuroblastoma cell differentiation highlights roles for SHP-2 and CDK16

Neuroblastoma is a highly heterogeneous embryonal solid tumor of the sympathetic nervous system. As some tumors can be treated to undergo differentiation, investigating this process can guide differentiation-based therapies of neuroblastoma. Here, we studied the role of E3 ubiquitin ligases Cbl and...

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Detalles Bibliográficos
Autores principales: Pedersen, Anna-Kathrine, Pfeiffer, Anamarija, Karemore, Gopal, Akimov, Vyacheslav, Bekker-Jensen, Dorte B., Blagoev, Blagoy, Francavilla, Chiara, Olsen, Jesper V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050387/
https://www.ncbi.nlm.nih.gov/pubmed/33889818
http://dx.doi.org/10.1016/j.isci.2021.102321