Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination

Here, we report that acute reduction in mitochondrial translation fidelity (MTF) causes ubiquitination of the inner mitochondrial membrane (IMM) proteins, including TRAP1 and CPOX, which occurs selectively in mitochondria with a severed outer mitochondrial membrane (OMM). Ubiquitinated IMM recruits...

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Detalles Bibliográficos
Autores principales: Oshima, Yumiko, Cartier, Etienne, Boyman, Liron, Verhoeven, Nicolas, Polster, Brian M., Huang, Weiliang, Kane, Maureen, Lederer, W. Jonathan, Karbowski, Mariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050842/
https://www.ncbi.nlm.nih.gov/pubmed/33851959
http://dx.doi.org/10.1083/jcb.202006043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050842/
https://www.ncbi.nlm.nih.gov/pubmed/33851959
http://dx.doi.org/10.1083/jcb.202006043

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