Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe

It is well established that short telomeres activate an ATM-driven DNA damage response that leads to senescence in terminally differentiated cells. However, technical limitations have hampered our understanding of how telomere shortening is signaled in human stem cells. Here, we show that telomere a...

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Detalles Bibliográficos
Autores principales: Vessoni, Alexandre T., Zhang, Tianpeng, Quinet, Annabel, Jeong, Ho-Chang, Munroe, Michael, Wood, Matthew, Tedone, Enzo, Vindigni, Alessandro, Shay, Jerry W., Greenberg, Roger A., Batista, Luis F.Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050844/
https://www.ncbi.nlm.nih.gov/pubmed/33851958
http://dx.doi.org/10.1083/jcb.202011014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050844/
https://www.ncbi.nlm.nih.gov/pubmed/33851958
http://dx.doi.org/10.1083/jcb.202011014

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