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Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe
It is well established that short telomeres activate an ATM-driven DNA damage response that leads to senescence in terminally differentiated cells. However, technical limitations have hampered our understanding of how telomere shortening is signaled in human stem cells. Here, we show that telomere a...
Autores principales: | Vessoni, Alexandre T., Zhang, Tianpeng, Quinet, Annabel, Jeong, Ho-Chang, Munroe, Michael, Wood, Matthew, Tedone, Enzo, Vindigni, Alessandro, Shay, Jerry W., Greenberg, Roger A., Batista, Luis F.Z. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050844/ https://www.ncbi.nlm.nih.gov/pubmed/33851958 http://dx.doi.org/10.1083/jcb.202011014 |
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