Retroviral prototype foamy virus intasome binding to a nucleosome target does not determine integration efficiency

Retroviral integrases must navigate host DNA packaged as chromatin during integration of the viral genome. Prototype foamy virus (PFV) integrase (IN) forms a tetramer bound to two viral DNA (vDNA) ends in a complex termed an intasome. PFV IN consists of four domains: the amino terminal extension dom...

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Detalles Bibliográficos
Autores principales: Kotlar, Randi M., Jones, Nathan D., Senavirathne, Gayan, Gardner, Anne M., Messer, Ryan K., Tan, Yow Yong, Rabe, Anthony J., Fishel, Richard, Yoder, Kristine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050864/
https://www.ncbi.nlm.nih.gov/pubmed/33744295
http://dx.doi.org/10.1016/j.jbc.2021.100550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050864/
https://www.ncbi.nlm.nih.gov/pubmed/33744295
http://dx.doi.org/10.1016/j.jbc.2021.100550

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