Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation

Although Polycomb repressive complex 2 (PRC2) is now recognized as an RNA-binding complex, the full range of binding motifs and why PRC2-RNA complexes often associate with active genes have not been elucidated. Here we identify high-affinity RNA motifs whose mutations weaken PRC2 binding and attenua...

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Detalles Bibliográficos
Autores principales: Rosenberg, Michael, Blum, Roy, Kesner, Barry, Aeby, Eric, Garant, Jean-Michel, Szanto, Attila, Lee, Jeannie T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050941/
https://www.ncbi.nlm.nih.gov/pubmed/33398172
http://dx.doi.org/10.1038/s41594-020-00535-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050941/
https://www.ncbi.nlm.nih.gov/pubmed/33398172
http://dx.doi.org/10.1038/s41594-020-00535-9

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