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Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation
Although Polycomb repressive complex 2 (PRC2) is now recognized as an RNA-binding complex, the full range of binding motifs and why PRC2-RNA complexes often associate with active genes have not been elucidated. Here we identify high-affinity RNA motifs whose mutations weaken PRC2 binding and attenua...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050941/ https://www.ncbi.nlm.nih.gov/pubmed/33398172 http://dx.doi.org/10.1038/s41594-020-00535-9 |