Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach

BACKGROUND: X-chromosomal genes contribute to sex differences, in particular during early development, when both X chromosomes are active in females. Double X-dosage shifts female pluripotent cells towards the naive stem cell state by increasing pluripotency factor expression, inhibiting the differe...

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Detalles Bibliográficos
Autores principales: Genolet, Oriana, Monaco, Anna A., Dunkel, Ilona, Boettcher, Michael, Schulz, Edda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051100/
https://www.ncbi.nlm.nih.gov/pubmed/33863351
http://dx.doi.org/10.1186/s13059-021-02321-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051100/
https://www.ncbi.nlm.nih.gov/pubmed/33863351
http://dx.doi.org/10.1186/s13059-021-02321-2

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