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Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach

BACKGROUND: X-chromosomal genes contribute to sex differences, in particular during early development, when both X chromosomes are active in females. Double X-dosage shifts female pluripotent cells towards the naive stem cell state by increasing pluripotency factor expression, inhibiting the differe...

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Detalles Bibliográficos
Autores principales:	Genolet, Oriana, Monaco, Anna A., Dunkel, Ilona, Boettcher, Michael, Schulz, Edda G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051100/ https://www.ncbi.nlm.nih.gov/pubmed/33863351 http://dx.doi.org/10.1186/s13059-021-02321-2

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