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Sentinel lymph node detection in endometrial cancer with indocyanine green: laparoscopic versus robotic approach

BACKGROUND: The aims of the present study were to assess bilateral sentinel lymph node (SLN) mapping with laparoscopic versus robotic approach, to assess variables affecting bilateral detection rates and to assess survival difference in patients with no/unilateral, compared to bilateral SLN detectio...

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Autores principales: Bizzarri, N, Restaino, S, Gueli Alletti, S, Monterossi, G, Gioè, A, La Fera, E, Gallotta, V, Fagotti, A, Scambia, G, Fanfani, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Universa Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051190/
https://www.ncbi.nlm.nih.gov/pubmed/33889857
http://dx.doi.org/10.52054/FVVO.13.1.002
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author Bizzarri, N
Restaino, S
Gueli Alletti, S
Monterossi, G
Gioè, A
La Fera, E
Gallotta, V
Fagotti, A
Scambia, G
Fanfani, F
author_facet Bizzarri, N
Restaino, S
Gueli Alletti, S
Monterossi, G
Gioè, A
La Fera, E
Gallotta, V
Fagotti, A
Scambia, G
Fanfani, F
author_sort Bizzarri, N
collection PubMed
description BACKGROUND: The aims of the present study were to assess bilateral sentinel lymph node (SLN) mapping with laparoscopic versus robotic approach, to assess variables affecting bilateral detection rates and to assess survival difference in patients with no/unilateral, compared to bilateral SLN detection. METHODS: This is a retrospective, single-centre, observational cohort study, including patients with endometrial cancer FIGO stage IA-IVB, treated with minimally invasive primary surgery and undergoing indocyanine green (ICG) injection to detect SLN, between January 2015 and December 2019. RESULTS: Of the 549 included patients, 286 (52.1%) and 263 (47.9%) underwent the laparoscopic and robotic approach respectively. 387 (70.5%) patients had bilateral SLN mapping, 102 (18.6%) and 60 (10.9%) had unilateral and no mapping, respectively. Patients who underwent the robotic approach were older (median 61 versus 64 years, p=0.046) and had a higher BMI (median 26.0 versus 34.8 kg/m2, p<0.001). No difference in any SLN mapping or in SLN bilateral detection was evident between the laparoscopic or robotic approach (p=0.892 and p=0.507 respectively). Patients with bilateral SLN detection in the entire cohort were younger (p<0.001) and had a better 3-year disease-free survival (DFS) compared to patients with no/unilateral SLN mapping (77.0% versus 66.3%, respectively, p=0.036). No 3-year overall survival (OS) difference was reported (p=0.491). CONCLUSION: SLN mapping and bilateral SLN detection with ICG in endometrial cancer was not different in the laparoscopic and robotic approach, even though patients undergoing the robotic approach were older and more obese. Bilateral SLN detection was associated with improved 3-year DFS, but not with 3-year OS, compared to no and unilateral SLN detection.
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spelling pubmed-80511902021-04-21 Sentinel lymph node detection in endometrial cancer with indocyanine green: laparoscopic versus robotic approach Bizzarri, N Restaino, S Gueli Alletti, S Monterossi, G Gioè, A La Fera, E Gallotta, V Fagotti, A Scambia, G Fanfani, F Facts Views Vis Obgyn Original Article BACKGROUND: The aims of the present study were to assess bilateral sentinel lymph node (SLN) mapping with laparoscopic versus robotic approach, to assess variables affecting bilateral detection rates and to assess survival difference in patients with no/unilateral, compared to bilateral SLN detection. METHODS: This is a retrospective, single-centre, observational cohort study, including patients with endometrial cancer FIGO stage IA-IVB, treated with minimally invasive primary surgery and undergoing indocyanine green (ICG) injection to detect SLN, between January 2015 and December 2019. RESULTS: Of the 549 included patients, 286 (52.1%) and 263 (47.9%) underwent the laparoscopic and robotic approach respectively. 387 (70.5%) patients had bilateral SLN mapping, 102 (18.6%) and 60 (10.9%) had unilateral and no mapping, respectively. Patients who underwent the robotic approach were older (median 61 versus 64 years, p=0.046) and had a higher BMI (median 26.0 versus 34.8 kg/m2, p<0.001). No difference in any SLN mapping or in SLN bilateral detection was evident between the laparoscopic or robotic approach (p=0.892 and p=0.507 respectively). Patients with bilateral SLN detection in the entire cohort were younger (p<0.001) and had a better 3-year disease-free survival (DFS) compared to patients with no/unilateral SLN mapping (77.0% versus 66.3%, respectively, p=0.036). No 3-year overall survival (OS) difference was reported (p=0.491). CONCLUSION: SLN mapping and bilateral SLN detection with ICG in endometrial cancer was not different in the laparoscopic and robotic approach, even though patients undergoing the robotic approach were older and more obese. Bilateral SLN detection was associated with improved 3-year DFS, but not with 3-year OS, compared to no and unilateral SLN detection. Universa Press 2021-03-31 /pmc/articles/PMC8051190/ /pubmed/33889857 http://dx.doi.org/10.52054/FVVO.13.1.002 Text en Copyright © 2021 Facts, Views & Vision https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bizzarri, N
Restaino, S
Gueli Alletti, S
Monterossi, G
Gioè, A
La Fera, E
Gallotta, V
Fagotti, A
Scambia, G
Fanfani, F
Sentinel lymph node detection in endometrial cancer with indocyanine green: laparoscopic versus robotic approach
title Sentinel lymph node detection in endometrial cancer with indocyanine green: laparoscopic versus robotic approach
title_full Sentinel lymph node detection in endometrial cancer with indocyanine green: laparoscopic versus robotic approach
title_fullStr Sentinel lymph node detection in endometrial cancer with indocyanine green: laparoscopic versus robotic approach
title_full_unstemmed Sentinel lymph node detection in endometrial cancer with indocyanine green: laparoscopic versus robotic approach
title_short Sentinel lymph node detection in endometrial cancer with indocyanine green: laparoscopic versus robotic approach
title_sort sentinel lymph node detection in endometrial cancer with indocyanine green: laparoscopic versus robotic approach
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051190/
https://www.ncbi.nlm.nih.gov/pubmed/33889857
http://dx.doi.org/10.52054/FVVO.13.1.002
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