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Structure of 3′-PO(4)/5′-OH RNA ligase RtcB in complex with a 5′-OH oligonucleotide
RtcB enzymes comprise a widely distributed family of manganese- and GTP-dependent RNA repair enzymes that join 2′,3′-cyclic phosphate ends to 5′-OH ends via RtcB-(histidinyl-N)–GMP, RNA 3′-phosphate, and RNA(3′)pp(5′)G intermediates. RtcB can ligate either 5′-OH RNA or 5′-OH DNA strands in vitro. Th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051266/ https://www.ncbi.nlm.nih.gov/pubmed/33619169 http://dx.doi.org/10.1261/rna.078692.121 |