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Novel chimeric TLR2/NOD2 agonist CL429 exhibited significant radioprotective effects in mice
Severe ionizing radiation causes the acute lethal damage of haematopoietic system and gastrointestinal tract. Here, we found CL429, the novel chimeric TLR2/NOD2 agonist, exhibited significant radioprotective effects in mice. CL429 increased mice survival, protected mice against the lethal damage of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051721/ https://www.ncbi.nlm.nih.gov/pubmed/33609010 http://dx.doi.org/10.1111/jcmm.16252 |
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author | Cheng, Ying Du, Jicong Liu, Ruling Dong, Suhe Cai, Jianming Gao, Fu Liu, Cong |
author_facet | Cheng, Ying Du, Jicong Liu, Ruling Dong, Suhe Cai, Jianming Gao, Fu Liu, Cong |
author_sort | Cheng, Ying |
collection | PubMed |
description | Severe ionizing radiation causes the acute lethal damage of haematopoietic system and gastrointestinal tract. Here, we found CL429, the novel chimeric TLR2/NOD2 agonist, exhibited significant radioprotective effects in mice. CL429 increased mice survival, protected mice against the lethal damage of haematopoietic system and gastrointestinal tract. CL429 was more effective than equivalent amounts of monospecific (TLR2 or NOD2) and combination (TLR2 + NOD2) of molecules in preventing radiation‐induced death. The radioprotection of CL429 was mainly mediated by activating TLR2 and partially activating NOD2. CL429‐induced radioprotection was largely dependent on the activation of TLR2‐MyD88‐NF‐κB signalling pathway. In conclusion, the data suggested that the co‐activation of TLR2 and NOD2 could induce significant synergistic radioprotective effects and CL429 might be a potential high‐efficiency selective agent. |
format | Online Article Text |
id | pubmed-8051721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80517212021-04-21 Novel chimeric TLR2/NOD2 agonist CL429 exhibited significant radioprotective effects in mice Cheng, Ying Du, Jicong Liu, Ruling Dong, Suhe Cai, Jianming Gao, Fu Liu, Cong J Cell Mol Med Original Articles Severe ionizing radiation causes the acute lethal damage of haematopoietic system and gastrointestinal tract. Here, we found CL429, the novel chimeric TLR2/NOD2 agonist, exhibited significant radioprotective effects in mice. CL429 increased mice survival, protected mice against the lethal damage of haematopoietic system and gastrointestinal tract. CL429 was more effective than equivalent amounts of monospecific (TLR2 or NOD2) and combination (TLR2 + NOD2) of molecules in preventing radiation‐induced death. The radioprotection of CL429 was mainly mediated by activating TLR2 and partially activating NOD2. CL429‐induced radioprotection was largely dependent on the activation of TLR2‐MyD88‐NF‐κB signalling pathway. In conclusion, the data suggested that the co‐activation of TLR2 and NOD2 could induce significant synergistic radioprotective effects and CL429 might be a potential high‐efficiency selective agent. John Wiley and Sons Inc. 2021-02-19 2021-04 /pmc/articles/PMC8051721/ /pubmed/33609010 http://dx.doi.org/10.1111/jcmm.16252 Text en © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Cheng, Ying Du, Jicong Liu, Ruling Dong, Suhe Cai, Jianming Gao, Fu Liu, Cong Novel chimeric TLR2/NOD2 agonist CL429 exhibited significant radioprotective effects in mice |
title | Novel chimeric TLR2/NOD2 agonist CL429 exhibited significant radioprotective effects in mice |
title_full | Novel chimeric TLR2/NOD2 agonist CL429 exhibited significant radioprotective effects in mice |
title_fullStr | Novel chimeric TLR2/NOD2 agonist CL429 exhibited significant radioprotective effects in mice |
title_full_unstemmed | Novel chimeric TLR2/NOD2 agonist CL429 exhibited significant radioprotective effects in mice |
title_short | Novel chimeric TLR2/NOD2 agonist CL429 exhibited significant radioprotective effects in mice |
title_sort | novel chimeric tlr2/nod2 agonist cl429 exhibited significant radioprotective effects in mice |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051721/ https://www.ncbi.nlm.nih.gov/pubmed/33609010 http://dx.doi.org/10.1111/jcmm.16252 |
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