Comprehensive assessment of amino acid substitutions in the trimeric RNA polymerase complex of influenza A virus detected in clinical trials of baloxavir marboxil

BACKGROUND: Baloxavir marboxil (BXM) is an approved drug that selectively targets cap‐dependent endonuclease on PA subunit in the RNA polymerase complex of influenza A and B viruses. Amino acid substitutions at position 38 in the PA subunit were identified as a major pathway for reduced susceptibili...

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Detalles Bibliográficos
Autores principales: Hashimoto, Takashi, Baba, Keiko, Inoue, Kae, Okane, Miyako, Hata, Satoshi, Shishido, Takao, Naito, Akira, Wildum, Steffen, Omoto, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051730/
https://www.ncbi.nlm.nih.gov/pubmed/33099886
http://dx.doi.org/10.1111/irv.12821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051730/
https://www.ncbi.nlm.nih.gov/pubmed/33099886
http://dx.doi.org/10.1111/irv.12821

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