Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies

Genetic studies have shifted to sequencing-based rare variants discovery after decades of success in identifying common disease variants by Genome-Wide Association Studies using Single Nucleotide Polymorphism chips. Sequencing-based studies require large sample sizes for statistical power and theref...

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Detalles Bibliográficos
Autores principales: Wickland, Daniel P., Ren, Yingxue, Sinnwell, Jason P., Reddy, Joseph S., Pottier, Cyril, Sarangi, Vivekananda, Carrasquillo, Minerva M., Ross, Owen A., Younkin, Steven G., Ertekin-Taner, Nilüfer, Rademakers, Rosa, Hudson, Matthew E., Mainzer, Liudmila Sergeevna, Biernacka, Joanna M., Asmann, Yan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051815/
https://www.ncbi.nlm.nih.gov/pubmed/33861770
http://dx.doi.org/10.1371/journal.pone.0249305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051815/
https://www.ncbi.nlm.nih.gov/pubmed/33861770
http://dx.doi.org/10.1371/journal.pone.0249305

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