Blockade of 6-phosphogluconate dehydrogenase generates CD8(+) effector T cells with enhanced anti-tumor function

Although T cell expansion depends on glycolysis, T effector cell differentiation requires signaling via the production of reactive oxygen species (ROS). Because the pentose phosphate pathway (PPP) regulates ROS by generating nicotinamide adenine dinucleotide phosphate (NADPH), we examined how PPP bl...

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Detalles Bibliográficos
Autores principales: Daneshmandi, Saeed, Cassel, Teresa, Lin, Penghui, Higashi, Richard M., Wulf, Gerburg M., Boussiotis, Vassiliki A., Fan, Teresa W.-M., Seth, Pankaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051863/
https://www.ncbi.nlm.nih.gov/pubmed/33691103
http://dx.doi.org/10.1016/j.celrep.2021.108831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051863/
https://www.ncbi.nlm.nih.gov/pubmed/33691103
http://dx.doi.org/10.1016/j.celrep.2021.108831

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