Crystal structure of ADAMTS13 CUB domains reveals their role in global latency

ADAMTS13 is a plasma metalloprotease that is essential for the regulation of von Willebrand factor (VWF) function, mediator of platelet recruitment to sites of blood vessel damage. ADAMTS13 function is dynamically regulated by structural changes induced by VWF binding that convert it from a latent t...

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Detalles Bibliográficos
Autores principales: Kim, H. J., Xu, Y., Petri, A., Vanhoorelbeke, K., Crawley, J. T. B., Emsley, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051872/
https://www.ncbi.nlm.nih.gov/pubmed/33863735
http://dx.doi.org/10.1126/sciadv.abg4403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051872/
https://www.ncbi.nlm.nih.gov/pubmed/33863735
http://dx.doi.org/10.1126/sciadv.abg4403

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