Rational antibody design for undruggable targets using kinetically controlled biomolecular probes

Several important drug targets, e.g., ion channels and G protein–coupled receptors, are extremely difficult to approach with current antibody technologies. To address these targets classes, we explored kinetically controlled proteases as structural dynamics–sensitive druggability probes in native-st...

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Detalles Bibliográficos
Autores principales: Trkulja, Carolina L., Jungholm, Oscar, Davidson, Max, Jardemark, Kent, Marcus, Monica M., Hägglund, Jessica, Karlsson, Anders, Karlsson, Roger, Bruton, Joseph, Ivarsson, Niklas, Srinivasa, Sreesha P., Cavallin, Alexandra, Svensson, Peder, Jeffries, Gavin D. M., Christakopoulou, Maria-Nefeli, Reymer, Anna, Ashok, Anaswara, Willman, Gabriella, Papadia, Daniela, Johnsson, Emma, Orwar, Owe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051879/
https://www.ncbi.nlm.nih.gov/pubmed/33863724
http://dx.doi.org/10.1126/sciadv.abe6397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051879/
https://www.ncbi.nlm.nih.gov/pubmed/33863724
http://dx.doi.org/10.1126/sciadv.abe6397

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